Prostate-Specific Antigen testing in men between 40 and 70 years in Brazil: database from a check-up program
Int. braz. j. urol
;
40(6): 745-752, Nov-Dec/2014. tab
Article
Dans Anglais
| LILACS
| ID: lil-735993
ABSTRACT
Objectives To evaluate the PSA in a large population of Brazilian men undergone to check up, and correlate the PSA cutoffs with prostate size and urinary symptoms. Materials and Methods This is a cross sectional study performed with men between 40 and 70 years undergone to check-up. All men were undergone to urological evaluation, digital rectal examination, prostate-specific antigen, and ultrasonography The exclusion criteria were men who used testosterone in the last six months, or who were using 5 alpha-reductase inhibitors. Results A total of 5015 men with an average age of 49.0 years completed the study. Most men were white and asymptomatic. The PSA in the three different aging groups were 0.9 ± 0.7ng/dL for men between 40 and 50; 1.2 ± 0.5ng/dL for men between 50 and 60; and 1.7 ± 1.5ng/dL for men greater than 60 years (p=0.001). A total of 192 men had PSA between 2.5 and 4ng/ml. From these men 130 were undergone to prostate biopsy. The predictive positive value of biopsy was 25% (32/130). In the same way, 100 patients had PSA >4ng/mL. From these men, 80 were undergone to prostate biopsy. In this group, the predictive positive value of biopsy was 40% (32/100). The Gleason score was 6 in 19 men (60%), 7 in 10 men (31%) and 8 in 3 men (9%). Conclusions The PSA level of Brazilian men undergone to check up was low. There was a positive correlation with aging, IPSS and prostate size. .
Texte intégral:
Disponible
Indice:
LILAS (Amériques)
Sujet Principal:
Prostate
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Tumeurs de la prostate
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Antigène spécifique de la prostate
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Dépistage précoce du cancer
Type d'étude:
Etude diagnostique
/
Études d'évaluation
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Étude observationnelle
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Étude de prévalence
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Étude pronostique
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Facteurs de risque
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Étude de dépistage
Limites du sujet:
Adulte
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Adulte très âgé
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Humains
/
Mâle
Pays comme sujet:
Amérique du Sud
/
Brésil
langue:
Anglais
Texte intégral:
Int. braz. j. urol
Thème du journal:
Urologie
Année:
2014
Type:
Article
Pays d'affiliation:
Brésil
Institution/Pays d'affiliation:
Universidade Federal de Sao Paulo/BR
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