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Effects of PDE type 5 inhibitors on Left Ventricular Diastolic Dysfunction in Resistant Hypertension / Efeitos dos Inibidores da PDE do Tipo 5 sobre a Disfunção Diastólica Ventricular Esquerda na Hipertensão Arterial Resistente
Faria, Ana Paula Cabral de; Modolo, Rodrigo; Moreno, Beatriz Vaz Domingues; Moreno, Heitor.
  • Faria, Ana Paula Cabral de; Universidade Estadual de Campinas. Faculdade de Ciências Médicas. São Paulo. BR
  • Modolo, Rodrigo; Universidade Estadual de Campinas. Faculdade de Ciências Médicas. São Paulo. BR
  • Moreno, Beatriz Vaz Domingues; Universidade Estadual de Campinas. Faculdade de Ciências Médicas. São Paulo. BR
  • Moreno, Heitor; Universidade Estadual de Campinas. Faculdade de Ciências Médicas. São Paulo. BR
Arq. bras. cardiol ; 104(1): 85-89, 01/2015. graf
Article Dans Anglais | LILACS | ID: lil-741125
ABSTRACT
Resistant hypertension (RHTN) is a multifactorial disease characterized by blood pressure (BP) levels above goal (140/90 mmHg) in spite of the concurrent use of three or more antihypertensive drugs of different classes. Moreover, it is well known that RHTN subjects have high prevalence of left ventricular diastolic dysfunction (LVDD), which leads to increased risk of heart failure progression. This review gathers data from studies evaluating the effects of phosphodiesterase-5 (PDE-5) inhibitors (administration of acute sildenafil and short-term tadalafil) on diastolic function, biochemical and hemodynamic parameters in patients with RHTN. Acute study with sildenafil treatment found that inhibition of PDE-5 improved hemodynamic parameters and diastolic relaxation. In addition, short-term study with the use of tadalafil demonstrated improvement of LVDD, cGMP and BNP-32 levels, regardless of BP reduction. No endothelial function changes were observed in the studies. The findings of acute and short-term studies revealed potential therapeutic effects of IPDE-5 drugs on LVDD in RHTN patients.
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Texte intégral: Disponible Indice: LILAS (Amériques) Sujet Principal: Dysfonction ventriculaire gauche / Défaillance cardiaque diastolique / Hypertension artérielle Type d'étude: Facteurs de risque Limites du sujet: Humains langue: Anglais Texte intégral: Arq. bras. cardiol Thème du journal: Cardiologie Année: 2015 Type: Article Pays d'affiliation: Brésil Institution/Pays d'affiliation: Universidade Estadual de Campinas/BR

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Texte intégral: Disponible Indice: LILAS (Amériques) Sujet Principal: Dysfonction ventriculaire gauche / Défaillance cardiaque diastolique / Hypertension artérielle Type d'étude: Facteurs de risque Limites du sujet: Humains langue: Anglais Texte intégral: Arq. bras. cardiol Thème du journal: Cardiologie Année: 2015 Type: Article Pays d'affiliation: Brésil Institution/Pays d'affiliation: Universidade Estadual de Campinas/BR