Inflammatory response of Haemophilus influenzae biotype aegyptius causing Brazilian Purpuric Fever
Braz. j. microbiol
;
45(4): 1449-1454, Oct.-Dec. 2014. ilus, tab
Article
Dans Anglais
| LILACS
| ID: lil-741299
ABSTRACT
The Brazilian Purpuric Fever (BPF) is a systemic disease with many clinical features of meningococcal sepsis and is usually preceded by purulent conjunctivitis. The illness is caused by Haemophilus influenza biogroup aegyptius, which was associated exclusively with conjunctivitis. In this work construction of the las gene, hypothetically responsible for this virulence, were fusioned with ermAM cassette in Neisseria meningitidis virulent strains and had its DNA transfer to non BPF H. influenzae strains. The effect of the las transfer was capable to increase the cytokines TNFα and IL10 expression in Hec-1B cells line infected with these transformed mutants (in eight log scale of folding change RNA expression). This is the first molecular study involving the las transfer to search an elucidation of the pathogenic factors by horizontal intergeneric transfer from meningococci to H. influenzae.
Texte intégral:
Disponible
Indice:
LILAS (Amériques)
Sujet Principal:
Haemophilus influenzae
/
Cytokines
/
Facteurs de virulence
/
Cellules épithéliales
/
Infections à Haemophilus
Limites du sujet:
Humains
Pays comme sujet:
Amérique du Sud
/
Brésil
langue:
Anglais
Texte intégral:
Braz. j. microbiol
Thème du journal:
Microbiologie
Année:
2014
Type:
Article
/
descriptif de projet
Pays d'affiliation:
Brésil
Institution/Pays d'affiliation:
State University of Campinas/BR
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