The use of halloysite clay and carboxyl-functionalised multi-walled carbon nanotubes for recombinant LipL32 antigen delivery enhanced the IgG response
Mem. Inst. Oswaldo Cruz
;
110(1): 134-137, 03/02/2015. graf
Article
Dans Anglais
| LILACS
| ID: lil-741614
ABSTRACT
We studied the feasibility of using halloysite clay nanotubes (HNTs) and carboxyl-functionalised multi-walled carbon nanotubes (COOH-MWCNTs) as antigen carriers to improve immune responses against a recombinant LipL32 protein (rLipL32). Immunisation using the HNTs or COOH-MWCNTs significantly increased the rLipL32-specific IgG antibody titres (p < 0.05) of Golden Syrian hamsters. None of the vaccines tested conferred protection against a challenge using a virulent Leptospira interrogans strain. These results demonstrated that nanotubes can be used as antigen carriers for delivery in hosts and the induction of a humoral immune response against purified leptospiral antigens used in subunit vaccine preparations.
Texte intégral:
Disponible
Indice:
LILAS (Amériques)
Sujet Principal:
Hydrates de carbone alimentaires
/
Fibre alimentaire
/
Qualité alimentaire
/
Contrôle des aliments
/
Malus
/
Fruit
/
Modèles biologiques
Type d'étude:
Etude diagnostique
/
Études d'évaluation
/
Étude pronostique
Pays comme sujet:
Europe
langue:
Anglais
Texte intégral:
Mem. Inst. Oswaldo Cruz
Thème du journal:
Médecine tropicale
/
Parasitologie
Année:
2015
Type:
Article
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