Parecoxib reduces renal injury in an ischemia/reperfusion model in rats
Acta cir. bras
;
30(4): 270-276, 04/2015. tab, graf
Article
Dans Anglais
| LILACS
| ID: lil-744283
ABSTRACT
PURPOSE:
To evaluate the effect of parecoxib (an NSAID) on renal function by measuring plasma NGAL (serum neutrophil gelatinase-associated lipocalin) levels in an induced-ischemia rat model.METHODS:
Forty male Wistar rats were randomly assigned to one of four groups Ischemia (I), Ischemia/parecoxib (IP), No-ischemia (NI), and No-ischemia/parecoxib (NIP). Body weight, mean arterial pressure, heart rate, body temperature, NGAL levels, and renal histology were compared across groups.RESULTS:
The Ischemia (I) group, which did not receive parecoxib, showed the highest NGAL levels (p=0.001), while the IP group, which received the medication, had NGAL levels similar to those of the non-ischemic (NI and NIP) groups.CONCLUSION:
Parecoxib resulted in renal protection in this experimental model. .
Texte intégral:
Disponible
Indice:
LILAS (Amériques)
Sujet Principal:
Lésion d'ischémie-reperfusion
/
Modèles animaux de maladie humaine
/
Atteinte rénale aigüe
/
Isoxazoles
/
Rein
Type d'étude:
Étude observationnelle
/
Étude pronostique
/
Facteurs de risque
/
Revues systématiques évaluées
Limites du sujet:
Animaux
langue:
Anglais
Texte intégral:
Acta cir. bras
Thème du journal:
Chirurgie générale
/
Procedimentos Cir£rgicos Operat¢rios
Année:
2015
Type:
Article
Pays d'affiliation:
Brésil
Institution/Pays d'affiliation:
UNESP/BR
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