Toll-like receptor 3 gene polymorphisms are not associated with the risk of hepatitis B and hepatitis C virus infection
Rev. Soc. Bras. Med. Trop
; Rev. Soc. Bras. Med. Trop;48(2): 136-142, mar-apr/2015. tab, graf
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BR1.1
ABSTRACT
INTRODUCTION:
The present study investigated the prevalence of two single-nucleotide polymorphisms (SNPs) in the Toll-like receptor 3 (TLR3) gene in patients infected with hepatitis B virus (HBV) and hepatitis C virus (HCV).METHODS:
Samples collected from HCV (n = 74) and HBV (n = 35) carriers were subjected to quantitative real-time PCR (qPCR) to detect the presence of the SNPs rs5743305 and rs3775291 in TLR3 and to measure the following biomarkers alanine aminotransferase (ALT), aspartate aminotransferase (AST), gamma-glutamyl transpeptidase (GGT), and prothrombin time (PT). A healthy control group was investigated and consisted of 299 HCV- and HBV-seronegative individuals.RESULTS:
No significant differences in allele, genotype and haplotype frequencies were observed between the investigated groups, and no association was observed between the polymorphisms and histopathological results. Nevertheless, genotypes TA/AA (rs5743305) and GG (rs3775291) appear to be associated with higher levels of ALT (p<0.01), AST (p<0.05) and PT (p<0.05). In addition, genotypes TT (rs5743305; p<0.05) and GG (rs3775291; p<0.05) were associated with higher GGT levels.CONCLUSIONS:
This genetic analysis revealed the absence of an association between the polymorphisms investigated and susceptibility to HBV and HCV infection; however, these polymorphisms might be associated with a greater degree of biliary damage during the course of HCV infection. .Mots clés
Texte intégral:
1
Indice:
LILACS
Sujet Principal:
Hépatite B chronique
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Hépatite C chronique
Type d'étude:
Etiology_studies
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Risk_factors_studies
Limites du sujet:
Adult
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Aged
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Aged80
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Female
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Humans
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Male
langue:
En
Texte intégral:
Rev. Soc. Bras. Med. Trop
Thème du journal:
MEDICINA TROPICAL
Année:
2015
Type:
Article
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Project document