Increased circulating macrophage migration inhibitory factor levels are associated with coronary artery disease
Clinics
;
70(3): 169-172, 03/2015. tab
Article
Dans Anglais
| LILACS
| ID: lil-747107
ABSTRACT
BACKGROUND:
To evaluate the macrophage migration inhibitory factor and E-selectin levels in patients with acute coronary syndrome. MATERIALS/METHODS:
We examined the plasma migration inhibitory factor and E-selectin levels in 87 patients who presented with chest pain at our hospital. The patients were classified into two groups according to their cardiac status. Sixty-five patients had acute myocardial infarction, and 22 patients had non-cardiac chest pain (non-coronary disease). We designated the latter group of patients as the control group. The patients who presented with acute myocardial infarction were further divided into two subgroups ST-elevated myocardial infarction (n = 30) and non-ST elevated myocardial infarction (n = 35).RESULTS:
We found higher plasma migration inhibitory factor levels in both acute myocardial infarction subgroups than in the control group. However, the E-selectin levels were similar between the acute myocardial infarction and control patients. In addition, we did not find a significant difference in the plasma migration inhibitory factor levels between the ST elevated myocardial infarction and NST-elevated myocardial infarction subgroups.DISCUSSION:
The circulating concentrations of migration inhibitory factor were significantly increased in acute myocardial infarction patients, whereas the soluble E-selectin levels were similar between acute myocardial infarction patients and control subjects. Our results suggest that migration inhibitory factor may play a role in the atherosclerotic process. .
Texte intégral:
Disponible
Indice:
LILAS (Amériques)
Sujet Principal:
Lymphocytes T cytotoxiques
/
Tumeurs mammaires de l'animal
/
Interféron gamma
/
Lymphocytes T auxiliaires
/
Sphéroïdes de cellules
Type d'étude:
Facteurs de risque
Limites du sujet:
Animaux
langue:
Anglais
Texte intégral:
Clinics
Thème du journal:
Médicament
Année:
2015
Type:
Article
Pays d'affiliation:
Turquie
Institution/Pays d'affiliation:
Izmir Bozyaka Training and Research Hospital/TR
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