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Cortical spreading depression in migraine-time to reconsider? / Depressão alastrante cortical na enxaqueca – hora de reconsiderar?
McComas, Alan J; Upton, Adrian R M.
  • McComas, Alan J; McMaster University. Department of Medicine. Hamilton Ontario. CA
  • Upton, Adrian R M; McMaster University. Department of Medicine. Hamilton Ontario. CA
Arq. neuropsiquiatr ; 73(8): 714-721, 08/2015. tab, graf
Article Dans Anglais | LILACS | ID: lil-753044
ABSTRACT
New evidence concerning the pathophysiology of migraine has come from the results of therapeutic transcranial magnetic stimulation (tTMS). The instantaneous responses to single pulses applied during the aura or headache phase, together with a number of other observations, make it unlikely that cortical spreading depression is involved in migraine. tTMS is considered to act by abolishing abnormal impulse activity in cortical pyramidal neurons and a suggestion is made as to how this activity could arise.
RESUMO
Novas evidências referentes à fisiopatologia da enxaqueca são o resultado de estimulação magnética transcraniana terapêutica (tTMS). As respostas imediatas a pulsos simples aplicados durante as fases de aura ou de cefaleia, em associação a diversas outras observações, tornam improvável a ideia de que a depressão alastrante esteja envolvida na enxaqueca. Considera-se que tTMS tenha sua ação abolindo atividade anormal de impulsos em neurônios corticais piramidais, sugerindo que esta atividade tenha um papel desencadeante.
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Texte intégral: Disponible Indice: LILAS (Amériques) Sujet Principal: Dépression corticale envahissante / Stimulation magnétique transcrânienne / Migraines Limites du sujet: Humains langue: Anglais Texte intégral: Arq. neuropsiquiatr Thème du journal: Neurologie / Psychiatrie Année: 2015 Type: Article Pays d'affiliation: Canada Institution/Pays d'affiliation: McMaster University/CA

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Texte intégral: Disponible Indice: LILAS (Amériques) Sujet Principal: Dépression corticale envahissante / Stimulation magnétique transcrânienne / Migraines Limites du sujet: Humains langue: Anglais Texte intégral: Arq. neuropsiquiatr Thème du journal: Neurologie / Psychiatrie Année: 2015 Type: Article Pays d'affiliation: Canada Institution/Pays d'affiliation: McMaster University/CA