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Plasticity of neutrophils reveals modulatory capacity
Perobelli, SM; Galvani, RG; Gonçalves-Silva, T; Xavier, CR; Nóbrega, A; Bonomo, A.
  • Perobelli, SM; Universidade Federal do Rio de Janeiro. Instituto de Microbiologia Paulo de Góes. Departamento de Imunologia. Rio de Janeiro. BR
  • Galvani, RG; Universidade Federal do Rio de Janeiro. Instituto de Microbiologia Paulo de Góes. Departamento de Imunologia. Rio de Janeiro. BR
  • Gonçalves-Silva, T; Universidade Federal do Rio de Janeiro. Instituto de Microbiologia Paulo de Góes. Departamento de Imunologia. Rio de Janeiro. BR
  • Xavier, CR; Universidade Federal do Rio de Janeiro. Instituto de Microbiologia Paulo de Góes. Departamento de Imunologia. Rio de Janeiro. BR
  • Nóbrega, A; Universidade Federal do Rio de Janeiro. Instituto de Microbiologia Paulo de Góes. Departamento de Imunologia. Rio de Janeiro. BR
  • Bonomo, A; Universidade Federal do Rio de Janeiro. Instituto de Microbiologia Paulo de Góes. Departamento de Imunologia. Rio de Janeiro. BR
Braz. j. med. biol. res ; 48(8): 665-675, 08/2015. graf
Article Dans Anglais | LILACS | ID: lil-753050
ABSTRACT
Neutrophils are widely known as proinflammatory cells associated with tissue damage and for their early arrival at sites of infection, where they exert their phagocytic activity, release their granule contents, and subsequently die. However, this view has been challenged by emerging evidence that neutrophils have other activities and are not so short-lived. Following activation, neutrophil effector functions include production and release of granule contents, reactive oxygen species (ROS), and neutrophil extracellular traps (NETs). Neutrophils have also been shown to produce a wide range of cytokines that have pro- or anti-inflammatory activity, adding a modulatory role for this cell, previously known as a suicide effector. The presence of cytokines almost always implies intercellular modulation, potentially unmasking interactions of neutrophils with other immune cells. In fact, neutrophils have been found to help B cells and to modulate dendritic cell (DC), macrophage, and T-cell activities. In this review, we describe some ways in which neutrophils influence the inflammatory environment in infection, cancer, and autoimmunity, regulating both innate and adaptive immune responses. These cells can switch phenotypes and exert functions beyond cytotoxicity against invading pathogens, extending the view of neutrophils beyond suicide effectors to include functions as regulatory and suppressor cells.
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Texte intégral: Disponible Indice: LILAS (Amériques) Sujet Principal: Activation des neutrophiles / Immunomodulation / Immunité acquise / Plasticité cellulaire / Granulocytes neutrophiles Limites du sujet: Humains langue: Anglais Texte intégral: Braz. j. med. biol. res Thème du journal: Biologie / Médicament Année: 2015 Type: Article / descriptif de projet Pays d'affiliation: Brésil Institution/Pays d'affiliation: Universidade Federal do Rio de Janeiro/BR

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Texte intégral: Disponible Indice: LILAS (Amériques) Sujet Principal: Activation des neutrophiles / Immunomodulation / Immunité acquise / Plasticité cellulaire / Granulocytes neutrophiles Limites du sujet: Humains langue: Anglais Texte intégral: Braz. j. med. biol. res Thème du journal: Biologie / Médicament Année: 2015 Type: Article / descriptif de projet Pays d'affiliation: Brésil Institution/Pays d'affiliation: Universidade Federal do Rio de Janeiro/BR