The role of immunohistochemistry in the Muir-Torre Syndrome
An. bras. dermatol
;
90(3,supl.1): 168-170, May-June 2015. ilus
Article
Dans Anglais
| LILACS
| ID: lil-755731
ABSTRACT
Muir-Torre Syndrome is defined by the coexistence of sebaceous skin tumors and internal malignancies. Mutations in the DNA mismatch repair genes are found in the inherited form of the disease, resulting in the absence of crucial enzymes involved with DNA replication process. This case describes a patient with sebaceous adenoma and colorectal carcinoma, meeting the criteria for Muir-Torre Syndrome. The immunohistochemical analysis of the skin lesion was an important tool to confirm the diagnosis, as it revealed nuclear negativity for MSH2 and MSH6.
.
Texte intégral:
Disponible
Indice:
LILAS (Amériques)
Sujet Principal:
Immunohistochimie
/
Carcinomes
/
Tumeurs colorectales
/
Syndrome de Muir-Torre
Limites du sujet:
Adulte
/
Humains
/
Mâle
langue:
Anglais
Texte intégral:
An. bras. dermatol
Thème du journal:
Dermatologie
Année:
2015
Type:
Article
Pays d'affiliation:
Brésil
Institution/Pays d'affiliation:
Universidade Federal do Amazonas/BR
Documents relatifs à ce sujet
MEDLINE
...
LILACS
LIS