Assessment of PSA-Age volume score in predicting positive prostate biopsy findings in Turkey
Int. braz. j. urol
;
41(5): 864-868, Sept.-Oct. 2015. tab
Article
Dans Anglais
| LILACS
| ID: lil-767040
ABSTRACT
ABSTRACT Objectives:
To evaluate PSA-age volume (AV) scores in predicting positive prostate biopsy findings in Turkey. Materials andMethods:
PSA-AV was calculated by multiplying the patient's age by the prostate volume and dividing it by the PSA level. Sensitivities and specificities of the PSA-AV were assessed by retrospective analysis of findings from 4,717 prostate biopsies.Results:
The population's average age was 63.71±7.63 years, the mean PSA level was 9.73±17.01ng/mL, the mean prostate volume was 44.46±23.88 cm3. Of the 4,717 prostate biopsies, 1,171 biopsy specimens (24.8%) were positive for prostate cancer. A PSA-AV score of 700 had a sensitivity and specificity of 95% and 15%, respectively. These values were similar to the sensitivity and specificity for a PSA cut-off of 4ng/mL (94% and 13%, respectively). Although the sensitivity of a PSA-AV cut-off of 700 in patients over 60 years was similar to the PSA cut-off of 4ng/mL and the age-adjusted PSA, in patients <60 years, its sensitivity was higher. While the sensitivities of a PSA-AV cut-off of 700 in patients with low prostate volume was higher than a PSA cut-off of 4ng/ mL, the sensitivities of both methods with moderate prostate volumes were similar.Conclusions:
Considering all the biopsies, the sensitivity and specificity of a PSA-AV of 700 for predicting positive biopsy findings were similar to a PSA of 4ng/mL. We suggest the PSA-AV cut-off of 700 should only be used in patients younger than 60 with low prostate volumes (<20cm3).
Texte intégral:
Disponible
Indice:
LILAS (Amériques)
Sujet Principal:
Prostate
/
Tumeurs de la prostate
/
Antigène spécifique de la prostate
Type d'étude:
Etude diagnostique
/
Étude observationnelle
/
Étude pronostique
/
Facteurs de risque
Limites du sujet:
Adulte
/
Adulte très âgé
/
Humains
/
Mâle
Pays comme sujet:
Asie
langue:
Anglais
Texte intégral:
Int. braz. j. urol
Thème du journal:
Urologie
Année:
2015
Type:
Article
Pays d'affiliation:
Turquie
Institution/Pays d'affiliation:
Celal Bayar University/TR
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