Vaccinia core transcription prevents in vitro depolymerization of polyribosomes in rabbit reticulocyte lysate
Braz. j. med. biol. res
;
20(6): 763-6, 1987. ilus
Article
Dans Anglais
| LILACS
| ID: lil-77433
ABSTRACT
When a rabbit reticulocyte lysate is incubated in the presence of vaccina cores, protein synthesis is umpaired at the level of the initiation step and the polyribosomes are depolymerized. However, when the same system is coupled with virus transcription a) protein synthesis is restored, b) the initiation step is not inhibited, and c) the polyribosomes are not disaggregated. A viral factor activated in the absence of virus transcription and not activated when RNA synthesis occurs may be involved in the early mechanism of protein synthesis inhibition by vaccinia virus
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Indice:
LILAS (Amériques)
Sujet Principal:
Polyribosomes
/
Réticulocytes
/
Transcription génétique
/
Vaccine
/
Techniques in vitro
/
Inhibiteurs de la synthèse protéique
/
Protéines
Limites du sujet:
Animaux
langue:
Anglais
Texte intégral:
Braz. j. med. biol. res
Thème du journal:
Biologie
/
Médicament
Année:
1987
Type:
Article
/
Congrès et conférence
/
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