Novel nonsense mutation in the katA gene of a catalase-negative Staphylococcus aureus strain
Braz. j. microbiol
;
47(1): 177-180, Jan.-Mar. 2016. tab
Article
Dans Anglais
| LILACS
| ID: lil-775102
ABSTRACT
Abstract We report the first description of a rare catalase-negative strain of Staphylococcus aureus in Chile. This new variant was isolated from blood and synovial tissue samples of a pediatric patient. Sequencing analysis revealed that this catalase-negative strain is related to ST10 strain, which has earlier been described in relation to S. aureus carriers. Interestingly, sequence analysis of the catalase gene katA revealed presence of a novel nonsense mutation that causes premature translational truncation of the C-terminus of the enzyme leading to a loss of 222 amino acids. Our study suggests that loss of catalase activity in this rare catalase-negative Chilean strain is due to this novel nonsense mutation in the katA gene, which truncates the enzyme to just 283 amino acids.
Texte intégral:
Disponible
Indice:
LILAS (Amériques)
Sujet Principal:
Infections à staphylocoques
/
Staphylococcus aureus
/
Catalase
/
Codon non-sens
Limites du sujet:
Enfant d'âge préscolaire
/
Humains
Pays comme sujet:
Amérique du Sud
/
Chili
langue:
Anglais
Texte intégral:
Braz. j. microbiol
Thème du journal:
Microbiologie
Année:
2016
Type:
Article
Pays d'affiliation:
Chili
Institution/Pays d'affiliation:
Molecular Genetics Subdepartment/CL
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