Your browser doesn't support javascript.
loading
Hair cortisol in drug-naïve first-episode individuals with psychosis
Andrade, Elvis H; Rizzo, Lucas B; Noto, Cristiano; Ota, Vanessa K; Gadelha, Ary; Daruy-Filho, Ledo; Tasso, Brazílio de C; Mansur, Rodrigo B; Cordeiro, Quirino; Belangero, Síntia I; Bressan, Rodrigo A; Grassi-Oliveira, Rodrigo; Brietzke, Elisa.
  • Andrade, Elvis H; Universidade Federal de São Paulo (UNIFESP). Laboratório Interdisciplinar de Neurociências Clínicas (LINC). São Paulo. BR
  • Rizzo, Lucas B; Universidade Federal de São Paulo (UNIFESP). Laboratório Interdisciplinar de Neurociências Clínicas (LINC). São Paulo. BR
  • Noto, Cristiano; Universidade Federal de São Paulo (UNIFESP). Laboratório Interdisciplinar de Neurociências Clínicas (LINC). São Paulo. BR
  • Ota, Vanessa K; Universidade Federal de São Paulo (UNIFESP). Laboratório Interdisciplinar de Neurociências Clínicas (LINC). São Paulo. BR
  • Gadelha, Ary; Universidade Federal de São Paulo (UNIFESP). Laboratório Interdisciplinar de Neurociências Clínicas (LINC). São Paulo. BR
  • Daruy-Filho, Ledo; Universidade Federal de São Paulo (UNIFESP). Laboratório Interdisciplinar de Neurociências Clínicas (LINC). São Paulo. BR
  • Tasso, Brazílio de C; Universidade Federal de São Paulo (UNIFESP). Laboratório Interdisciplinar de Neurociências Clínicas (LINC). São Paulo. BR
  • Mansur, Rodrigo B; Universidade Federal de São Paulo (UNIFESP). Laboratório Interdisciplinar de Neurociências Clínicas (LINC). São Paulo. BR
  • Cordeiro, Quirino; Universidade Federal de São Paulo (UNIFESP). Laboratório Interdisciplinar de Neurociências Clínicas (LINC). São Paulo. BR
  • Belangero, Síntia I; Universidade Federal de São Paulo (UNIFESP). Laboratório Interdisciplinar de Neurociências Clínicas (LINC). São Paulo. BR
  • Bressan, Rodrigo A; Universidade Federal de São Paulo (UNIFESP). Laboratório Interdisciplinar de Neurociências Clínicas (LINC). São Paulo. BR
  • Grassi-Oliveira, Rodrigo; Universidade Federal de São Paulo (UNIFESP). Laboratório Interdisciplinar de Neurociências Clínicas (LINC). São Paulo. BR
  • Brietzke, Elisa; Universidade Federal de São Paulo (UNIFESP). Laboratório Interdisciplinar de Neurociências Clínicas (LINC). São Paulo. BR
Braz. J. Psychiatry (São Paulo, 1999, Impr.) ; 38(1): 11-16, Jan.-Mar. 2016. tab, graf
Article Dans Anglais | LILACS | ID: lil-776491
ABSTRACT

Objectives:

To compare hair cortisol concentrations (HCC) in drug-naïve first-episode psychosis (FEP) patients and healthy controls and to investigate the correlations between HCC and psychopathology.

Methods:

Twenty-four drug-naïve FEP patients and 27 gender- and age-matched healthy control subjects were recruited. The Structured Clinical Interview for DSM-IV (SCID-1) was used to confirm/rule out diagnoses, and the Positive and Negative Symptoms Scale (PANSS) was used to assess symptom severity. Hair samples (2-3 cm long) obtained from the posterior vertex region of the scalp were processed in 1-cm segments considering a hair growth rate of 1 cm per month. The 1-cm segments were classified according to their proximity to the scalp segment A was the closest to the scalp and referred to the month prior to inclusion in the study. Segments B and C referred to the 2nd and 3rd months prior to the time of evaluation respectively. Hair steroid extraction was performed using a known protocol.

Results:

Two-way analysis of covariance (ANCOVA) with gender and age as covariates revealed a group effect (F1.106 = 4.899, p = 0.029) on HCC. Between-segment differences correlated with total PANSS score and with PANSS General Psychopathology subscale and total score.

Conclusions:

Our findings suggest that hypothalamic-pituitary-adrenal (HPA) axis, as assessed by long-term (3-month) cortisol concentration, is abnormal in the early stages of psychosis. The magnitude of changes in HCC over time prior to the FEP correlates to psychopathology. HPA axis abnormalities might begin prior to full-blown clinical presentation requiring hospital admission.
Sujets)


Texte intégral: Disponible Indice: LILAS (Amériques) Sujet Principal: Troubles psychotiques / Hydrocortisone / Poils Type d'étude: Guide de pratique / Étude observationnelle / Étude de prévalence / Étude pronostique / Recherche qualitative / Facteurs de risque Limites du sujet: Adulte / Femelle / Humains / Mâle langue: Anglais Texte intégral: Braz. J. Psychiatry (São Paulo, 1999, Impr.) Thème du journal: Psychiatrie Année: 2016 Type: Article Pays d'affiliation: Brésil Institution/Pays d'affiliation: Universidade Federal de São Paulo (UNIFESP)/BR

Documents relatifs à ce sujet

MEDLINE

...
LILACS

LIS


Texte intégral: Disponible Indice: LILAS (Amériques) Sujet Principal: Troubles psychotiques / Hydrocortisone / Poils Type d'étude: Guide de pratique / Étude observationnelle / Étude de prévalence / Étude pronostique / Recherche qualitative / Facteurs de risque Limites du sujet: Adulte / Femelle / Humains / Mâle langue: Anglais Texte intégral: Braz. J. Psychiatry (São Paulo, 1999, Impr.) Thème du journal: Psychiatrie Année: 2016 Type: Article Pays d'affiliation: Brésil Institution/Pays d'affiliation: Universidade Federal de São Paulo (UNIFESP)/BR