Borage oil attenuates progression of cardiac remodeling in rats after myocardial infarction
Acta cir. bras
;
31(3): 190-197, Mar. 2016. tab, graf
Article
Dans Anglais
| LILACS
| ID: lil-777097
ABSTRACT
ABSTRACT PURPOSE:
To investigate the effects of Borage oil on cardiac remodeling after myocardial infarction (MI).METHODS:
Male Wistar rats underwent ligation of the left coronary artery and divided into three groups MI (control), BO-18 (18 mg/kg of borage oil) and BO-180 (180 mg/kg of borage oil). After seven days, heart was arrested in diastole and processed for histological evaluation of MI size, LV dilation, myocyte hypertrophy, inflammatory infiltration and fibrosis in MI region and in remote region. The relative weight of the lung was used as a marker of heart failure. The MI size was comparable among groups.RESULTS:
Compared to control, BO treated groups showed lower weight of heart and lungs, reduced LV dilation and myocyte hypertrophy. Hemodynamic measurements were comparable. The treatment attenuated the inflammatory infiltration and fibrosis in remote myocardium.CONCLUSION:
Borage oil attenuates progression of cardiac remodeling after myocardial infarction and congestive heart failure.
Texte intégral:
Disponible
Indice:
LILAS (Amériques)
Sujet Principal:
Huiles végétales
/
Acide gamma linolénique
/
Remodelage ventriculaire
/
Ventricules cardiaques
/
Anti-inflammatoires
/
Infarctus du myocarde
Limites du sujet:
Animaux
langue:
Anglais
Texte intégral:
Acta cir. bras
Thème du journal:
Chirurgie générale
/
Procedimentos Cir£rgicos Operat¢rios
Année:
2016
Type:
Article
Pays d'affiliation:
Brésil
Institution/Pays d'affiliation:
Universidade da Cidade de São Paulo/BR
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