Effects of aspirin-like drugs on Walker 256 tumor growth and cachexia in rats
Braz. j. med. biol. res
;
22(8): 1039-42, 1989. ilus, tab
Article
Dans Anglais
| LILACS
| ID: lil-77753
RESUMO
Several studies have shown the relationship between prostaglandins (PGs) and cell proliferation. Some PGs may trigger cell dibision or are involved in this process. This a=study analyzes the effect of PG biosyntheseis inhibitors on tumor growth in vivo and cachexia in Walker 256 tumor-bearing rats. Indomethacin markedly inhibited tumor growth (95.5% while ibuprofen and aspirin reduced tumor growth by 73.9% and 59.4%, respectively. In addition, all drug-treated rats partially recovered body weight and food intake as compared to the saline-treated group. These findings suggest that PG synthesis inhibitors improve cancer cachexia
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Indice:
LILAS (Amériques)
Sujet Principal:
Cachexie
/
Carcinosarcome Walker 256
/
Transformation cellulaire néoplasique
/
Acide acétylsalicylique
/
Ibuprofène
/
Indométacine
Limites du sujet:
Animaux
langue:
Anglais
Texte intégral:
Braz. j. med. biol. res
Thème du journal:
Biologie
/
Médicament
Année:
1989
Type:
Article
/
Congrès et conférence
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