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Morphometric analysis of feedforward pathways from the primary somatosensory area (S1) of rats
Sá, A L de; Bahia, C P; Correa, V C; Dias, I A; Batista, C; Gomes-Leal, W; Pinho, A L S; Houzel, J C; Picanço-Diniz, C W; Pereira, A.
  • Sá, A L de; Universidade Federal do Rio Grande do Norte. Instituto do Cérebro. Natal. BR
  • Bahia, C P; Universidade Federal do Rio Grande do Norte. Instituto do Cérebro. Natal. BR
  • Correa, V C; Universidade Federal do Rio Grande do Norte. Instituto do Cérebro. Natal. BR
  • Dias, I A; Universidade Federal do Rio Grande do Norte. Instituto do Cérebro. Natal. BR
  • Batista, C; Universidade Federal do Rio Grande do Norte. Instituto do Cérebro. Natal. BR
  • Gomes-Leal, W; Universidade Federal do Rio Grande do Norte. Instituto do Cérebro. Natal. BR
  • Pinho, A L S; Universidade Federal do Rio Grande do Norte. Instituto do Cérebro. Natal. BR
  • Houzel, J C; Universidade Federal do Rio Grande do Norte. Instituto do Cérebro. Natal. BR
  • Picanço-Diniz, C W; Universidade Federal do Rio Grande do Norte. Instituto do Cérebro. Natal. BR
  • Pereira, A; Universidade Federal do Rio Grande do Norte. Instituto do Cérebro. Natal. BR
Braz. j. med. biol. res ; 49(6): e5115, 2016. tab, graf
Article Dans Anglais | LILACS | ID: lil-781415
ABSTRACT
We used biotinylated dextran amine (BDA) to anterogradely label individual axons projecting from primary somatosensory cortex (S1) to four different cortical areas in rats. A major goal was to determine whether axon terminals in these target areas shared morphometric similarities based on the shape of individual terminal arbors and the density of two bouton types en passant (Bp) and terminaux (Bt). Evidence from tridimensional reconstructions of isolated axon terminal fragments (n=111) did support a degree of morphological heterogeneity establishing two broad groups of axon terminals. Morphological parameters associated with the complexity of terminal arbors and the proportion of beaded Bp vs stalked Bt were found to differ significantly in these two groups following a discriminant function statistical analysis across axon fragments. Interestingly, both groups occurred in all four target areas, possibly consistent with a commonality of presynaptic processing of tactile information. These findings lay the ground for additional work aiming to investigate synaptic function at the single bouton level and see how this might be associated with emerging properties in postsynaptic targets.
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Texte intégral: Disponible Indice: LILAS (Amériques) Sujet Principal: Cortex somatosensoriel / Terminaisons présynaptiques / Réseau nerveux Limites du sujet: Animaux langue: Anglais Texte intégral: Braz. j. med. biol. res Thème du journal: Biologie / Médicament Année: 2016 Type: Article / descriptif de projet Pays d'affiliation: Brésil Institution/Pays d'affiliation: Universidade Federal do Rio Grande do Norte/BR

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Texte intégral: Disponible Indice: LILAS (Amériques) Sujet Principal: Cortex somatosensoriel / Terminaisons présynaptiques / Réseau nerveux Limites du sujet: Animaux langue: Anglais Texte intégral: Braz. j. med. biol. res Thème du journal: Biologie / Médicament Année: 2016 Type: Article / descriptif de projet Pays d'affiliation: Brésil Institution/Pays d'affiliation: Universidade Federal do Rio Grande do Norte/BR