Respiratory syncytial virus seasonality in Brazil: implications for the immunisation policy for at-risk populations
Mem. Inst. Oswaldo Cruz
;
111(5): 294-301, May 2016. tab, graf
Article
Dans Anglais
| LILACS
| ID: lil-782051
ABSTRACT
Respiratory syncytial virus (RSV) infection is the leading cause of hospitalisation for respiratory diseases among children under 5 years old. The aim of this study was to analyse RSV seasonality in the five distinct regions of Brazil using time series analysis (wavelet and Fourier series) of the following indicators monthly positivity of the immunofluorescence reaction for RSV identified by virologic surveillance system, and rate of hospitalisations per bronchiolitis and pneumonia due to RSV in children under 5 years old (codes CID-10 J12.1, J20.5, J21.0 and J21.9). A total of 12,501 samples with 11.6% positivity for RSV (95% confidence interval 11 - 12.2), varying between 7.1 and 21.4% in the five Brazilian regions, was analysed. A strong trend for annual cycles with a stable stationary pattern in the five regions was identified through wavelet analysis of the indicators. The timing of RSV activity by Fourier analysis was similar between the two indicators analysed and showed regional differences. This study reinforces the importance of adjusting the immunisation period for high risk population with the monoclonal antibody palivizumab taking into account regional differences in seasonality of RSV.
Texte intégral:
Disponible
Indice:
LILAS (Amériques)
Sujet Principal:
Pneumopathie virale
/
Bronchiolite virale
/
Infections à virus respiratoire syncytial
/
Hospitalisation
Type d'étude:
Etude d'étiologie
/
Facteurs de risque
Limites du sujet:
Enfant d'âge préscolaire
/
Humains
Pays comme sujet:
Amérique du Sud
/
Brésil
langue:
Anglais
Texte intégral:
Mem. Inst. Oswaldo Cruz
Thème du journal:
Médecine tropicale
/
Parasitologie
Année:
2016
Type:
Article
Pays d'affiliation:
Brésil
Institution/Pays d'affiliation:
Faculdade de Medicina São Leopoldo Mandic/BR
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