Sevoflurane preconditioning during myocardial ischemia-reperfusion reduces infarct size and preserves autonomic control of circulation in rats
Acta cir. bras
;
31(5): 338-345, May 2016. tab, graf
Article
Dans Anglais
| LILACS
| ID: lil-783802
ABSTRACT
ABSTRACT PURPOSE:
To investigate the myocardial ischemia-reperfusion with sevoflurane anesthetic preconditioning (APC) would present beneficial effects on autonomic and cardiac function indexes after the acute phase of a myocardial ischemia-reperfusion.METHODS:
Twenty Wistar rats were allocated in three groups control (CON, n=10), myocardial infarction with sevoflurane (SEV, n=5) and infarcted without sevoflurane (INF, n=5). Myocardial ischemia (60 min) and reperfusion were performed by temporary coronary occlusion. Twenty-one days later, the systolic and diastolic function were evaluated by echocardiography; spectral analysis of the systolic arterial pressure (SAPV) and heart rate variability (HRV) were assessed. After the recording period, the infarct size (IS) was evaluated.RESULTS:
The INF group presented greater cardiac dysfunction and increased sympathetic modulation of the SAPV, as well as decreased alpha index and worse vagal modulation of the HRV. The SEV group exhibited attenuation of the systolic and diastolic dysfunction and preserved vagal modulation (square root of the mean squared differences of successive R-R intervals and high frequency) of HRV, as well as a smaller IS.CONCLUSION:
Sevoflurane preconditioning better preserved the cardiac function and autonomic modulation of the heart in post-acute myocardial infarction period.
Texte intégral:
Disponible
Indice:
LILAS (Amériques)
Sujet Principal:
Système nerveux autonome
/
Ischémie myocardique
/
Anesthésiques par inhalation
/
Préconditionnement ischémique myocardique
/
Éthers méthyliques
/
Infarctus du myocarde
Type d'étude:
Etude d'étiologie
/
Étude pronostique
Limites du sujet:
Animaux
langue:
Anglais
Texte intégral:
Acta cir. bras
Thème du journal:
Chirurgie générale
/
Procedimentos Cir£rgicos Operat¢rios
Année:
2016
Type:
Article
Pays d'affiliation:
Brésil
Institution/Pays d'affiliation:
Universidade de São Paulo (USP)/BR
Documents relatifs à ce sujet
MEDLINE
...
LILACS
LIS