Mid- and long-term anxiety levels associated with presymptomatic testing of Huntington's Disease, Machado-Joseph Disease, Machado-Joseph disease, and familial amyloid polyneuropathy
Braz. J. Psychiatry (São Paulo, 1999, Impr.)
;
38(2): 113-120, Apr.-June 2016. tab
Article
Dans Anglais
| LILACS
| ID: lil-784298
ABSTRACT
Objective:
To study anxiety as a variable of the mid- and long-term psychological impact of pre-symptomatic testing for three autosomal dominant late-onset disorders – Huntington’s disease (HD), Machado-Joseph disease (MJD) and familial amyloid polyneuropathy (FAP) TTR V30M – in a Portuguese sample.Methods:
This cross-sectional study included 203participants:
170 (83.7%) underwent pre-symptomatic testing for FAP, 29 (14.3%) for HD, and 4 (2%) for MJD. Of the 203 participants, 73 (36.0%) were asymptomatic carriers, 29 (14.5%) were symptomatic carriers, 9 (4.5%) were diagnosed with FAP and had a liver transplant, and 89 (44.5%) were non-carriers. Most were women (58.1%) and married (66.5%). The anxiety variable was assessed using the Zung Self-Rating Anxiety Scale (SAS).Results:
The anxiety scores were higher for symptomatic carriers and for those who underwent psychological support consultations over the years. For symptomatic carriers, the mean scores were superior to 40 points, which reflects clinical anxiety.Conclusion:
Although it was not possible to differentiate between the mid- and long-term psychological impacts, this study supports the conclusion that the proximity to the age of symptoms onset might be a trigger for anxiety.
Texte intégral:
Disponible
Indice:
LILAS (Amériques)
Sujet Principal:
Anxiété
/
Maladie de Huntington
/
Maladie de Machado-Joseph
/
Neuropathies amyloïdes familiales
/
Maladies asymptomatiques
Type d'étude:
Etude diagnostique
/
Étude observationnelle
/
Étude de prévalence
/
Étude pronostique
/
Recherche qualitative
/
Facteurs de risque
Limites du sujet:
Adulte
/
Adulte très âgé
/
Femelle
/
Humains
/
Mâle
Pays comme sujet:
Europe
langue:
Anglais
Texte intégral:
Braz. J. Psychiatry (São Paulo, 1999, Impr.)
Thème du journal:
Psychiatrie
Année:
2016
Type:
Article
Pays d'affiliation:
Portugal
Institution/Pays d'affiliation:
Centro de Genética Preditiva e Preventiva (CGPP)/PT
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