Bacterial chemistry-III: preliminary studies on Trypanosomal activities of Chromobacterium violaceum products
An. acad. bras. ciênc
;
61(1): 31-6, 1989. tab
Article
Dans Anglais
| LILACS
| ID: lil-78985
ABSTRACT
It has been found that the pigment-I from Chromobacterium violaceum, 3 [1,2 dihydro 5 (5 hydroxy 1H indol 3 yl) 2 oxo 3H pyrrol-3 ylidiene] 1,3 dihydro 2H indol 2 one, has trypanocide activity. The formylated derivatives, pigment-III, immobilized 100% of the Trypanosoma cruzi at a level of 46 micronM after 48h of interaction with a total growth inhibition in the same period. Pigment I exhibited low toxicity and a DNA synthesis inhibition similar to that of Nifurtimox, a known trypanocide compound
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Indice:
LILAS (Amériques)
Sujet Principal:
Inhibiteurs de protéases
/
Séquence d'acides aminés
langue:
Anglais
Texte intégral:
An. acad. bras. ciênc
Thème du journal:
Science
Année:
1989
Type:
Article
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