Skin barrier in atopic dermatitis: beyond filaggrin
An. bras. dermatol
;
91(4): 472-478, July-Aug. 2016. tab, graf
Article
Dans Anglais
| LILACS
| ID: lil-792439
ABSTRACT
Abstract Atopic dermatitis is a chronic inflammatory skin disease with a complex pathogenesis, where changes in skin barrier and imbalance of the immune system are relevant factors. The skin forms a mechanic and immune barrier, regulating water loss from the internal to the external environment, and protecting the individual from external aggressions, such as microorganisms, ultraviolet radiation and physical trauma. Main components of the skin barrier are located in the outer layers of the epidermis (such as filaggrin), the proteins that form the tight junction (TJ) and components of the innate immune system. Recent data involving skin barrier reveal new information regarding its structure and its role in the mechanic-immunological defense; atopic dermatitis (AD) is an example of a disease related to dysfunctions associated with this complex.
Texte intégral:
Disponible
Indice:
LILAS (Amériques)
Sujet Principal:
Eczéma atopique
/
Épiderme
/
Protéines de filaments intermédiaires
Limites du sujet:
Humains
langue:
Anglais
Texte intégral:
An. bras. dermatol
Thème du journal:
Dermatologie
Année:
2016
Type:
Article
Pays d'affiliation:
Brésil
Institution/Pays d'affiliation:
Universidade de São Paulo/BR
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