Your browser doesn't support javascript.
loading
Serum Clara cell 16-kDa protein levels and lung impairment in systemic sclerosis patients / Níveis séricos de proteína de células de Clara de 16 kDa e comprometimento pulmonar em pacientes com esclerose sistêmica
Olewicz-Gawlik, Anna; Trzybulska, Dorota; Kuznar-Kaminska, Barbara; Katulska, Katarzyna; Danczak-Pazdrowska, Aleksandra; Batura-Gabryel, Halina; Hrycaj, Pawel.
  • Olewicz-Gawlik, Anna; Poznan University of Medical Sciences. Department of Rheumatology and Clinical Immunology. Poznan. PL
  • Trzybulska, Dorota; Poznan University of Medical Sciences. Department of Rheumatology and Clinical Immunology. Poznan. PL
  • Kuznar-Kaminska, Barbara; Poznan University of Medical Sciences. Department of Rheumatology and Clinical Immunology. Poznan. PL
  • Katulska, Katarzyna; Poznan University of Medical Sciences. Department of Rheumatology and Clinical Immunology. Poznan. PL
  • Danczak-Pazdrowska, Aleksandra; Poznan University of Medical Sciences. Department of Rheumatology and Clinical Immunology. Poznan. PL
  • Batura-Gabryel, Halina; Poznan University of Medical Sciences. Department of Rheumatology and Clinical Immunology. Poznan. PL
  • Hrycaj, Pawel; Poznan University of Medical Sciences. Department of Rheumatology and Clinical Immunology. Poznan. PL
Rev. bras. reumatol ; 56(4): 309-313, July-Aug. 2016. tab, graf
Article Dans Anglais | LILACS | ID: lil-792766
ABSTRACT
ABSTRACT

Objective:

To assess clinical utility of serum Clara cell 16-kDa protein measurements in relation with staging system for systemic sclerosis associated interstitial lung disease. Materials and

methods:

Serum levels of Clara cell 16-kDa protein were determined by ELISA in 28 systemic sclerosis patients and 30 healthy controls, and correlated with staging system for systemic sclerosis associated interstitial lung disease in systemic sclerosis patients. Lung involvement was assessed functionally (body plethysmography, diffusing capacity of the lung for carbon monoxide) and radiologically (an average disease extent on high resolution computed tomography of the lungs) in SSc patients.

Results:

We observed statistically significant differences in serum Clara cell 16-kDa protein levels between systemic sclerosis patients and healthy controls only in non-smokers. However, serum Clara cell 16-kDa protein concentrations were significantly elevated in patients with high resolution computed tomography extent >20% in comparison to patients with high resolution computed tomography extent <20% (p = 0.01). They correlated positively with average disease extent on high resolution computed tomography (p = 0.04), an extent of a reticular pattern on high resolution computed tomography (p < 0.01), and negatively with a total lung capacity (p = 0.03) and the results of the 6-min walk test (p < 0.01).

Conclusions:

Clara cell 16-kDa protein levels can be considered as a supplemental serum biomarker for systemic sclerosis associated interstitial lung disease.
RESUMO
RESUMO

Objetivo:

Avaliar a utilidade clínica das medições séricas da proteína de células de Clara de 16-kDa (CC16) em relação ao sistema de estadiamento para doença pulmonar intersticial associada a esclerose sistêmica (DPI-ES).

Materiais e métodos:

Foram determinados os níveis séricos de CC16 por ELISA em 28 pacientes com ES e 30 controles saudáveis e correlacionados com o sistema de estadiamento para DPI-ES em pacientes com ES. O envolvimento pulmonar foi avaliado funcionalmente (pletismografia corporal, capacidade de difusão de monóxido de carbono) e radiologicamente (extensão média da doença na tomografia computadorizada de alta resolução dos pulmões, TCAR) em pacientes com ES.

Resultados:

Foram encontradas diferenças estatisticamente significativas nos níveis séricos de CC16 entre pacientes com ES e controles saudáveis apenas em não tabagistas. No entanto, as concentrações séricas de CC16 eram significativamente elevadas em pacientes com extensão > 20% na TCAR em comparação com pacientes com extensão < 20% na TCAR (p = 0,01). Os níveis séricos de CC16 se correlacionaram positivamente com a extensão média da doença na TCAR (p = 0,04) e com a extensão de padrão reticular na TCAR (p < 0,01) e negativamente com a capacidade pulmonar total (CPT) (p = 0,03) e com os resultados do teste de caminhada de seis minutos (p < 0,01).

Conclusões:

Os níveis de CC16 podem ser considerados como biomarcadores séricos suplementares para a DPI-ES.
Sujets)


Texte intégral: Disponible Indice: LILAS (Amériques) Sujet Principal: Pléthysmographie du corps entier / Sclérodermie systémique / Test ELISA / Pneumopathies interstitielles Limites du sujet: Humains langue: Anglais Texte intégral: Rev. bras. reumatol Thème du journal: Rhumatologie Année: 2016 Type: Article Pays d'affiliation: Pologne Institution/Pays d'affiliation: Poznan University of Medical Sciences/PL

Documents relatifs à ce sujet

MEDLINE

...
LILACS

LIS


Texte intégral: Disponible Indice: LILAS (Amériques) Sujet Principal: Pléthysmographie du corps entier / Sclérodermie systémique / Test ELISA / Pneumopathies interstitielles Limites du sujet: Humains langue: Anglais Texte intégral: Rev. bras. reumatol Thème du journal: Rhumatologie Année: 2016 Type: Article Pays d'affiliation: Pologne Institution/Pays d'affiliation: Poznan University of Medical Sciences/PL