Treatment of patients with aortic atherosclerotic disease with paclitaxel-associated lipid nanoparticles
Clinics
;
71(8): 435-439, Aug. 2016. tab
Article
Dans Anglais
| LILACS, SES-SP, SESSP-IDPCPROD, SES-SP
| ID: lil-794635
ABSTRACT
OBJECTIVE:
The toxicity of anti-cancer chemotherapeutic agents can be reduced by associating these compounds, such as the anti-proliferative agent paclitaxel, with a cholesterol-rich nanoemulsion (LDE) that mimics the lipid composition of low-density lipoprotein (LDL). When injected into circulation, the LDE concentrates the carried drugs in neoplastic tissues and atherosclerotic lesions. In rabbits, atherosclerotic lesion size was reduced by 65% following LDE-paclitaxel treatment. The current study aimed to test the effectiveness of LDE-paclitaxel on inpatients with aortic atherosclerosis.METHODS:
This study tested a 175 mg/m2 body surface area dose of LDE-paclitaxel (intravenous administration, 3/3 weeks for 6 cycles) in patients with aortic atherosclerosis who were aged between 69 and 86 yrs. A control group of 9 untreated patients with aortic atherosclerosis (72-83 yrs) was also observed.RESULTS:
The LDE-paclitaxel treatment elicited no important clinical or laboratory toxicities. Images were acquired via multiple detector computer tomography angiography (64-slice scanner) before treatment and at 1-2 months after treatment. The images showed that the mean plaque volume in the aortic artery wall was reduced in 4 of the 8 patients, while in 3 patients it remained unchanged and in one patient it increased. In the control group, images were acquired twice with an interval of 6-8 months. None of the patients in this group exhibited a reduction in plaque volume; in contrast, the plaque volume increased in three patients and remained stable in four patients. During the study period, one death unrelated to the treatment occurred in the LDE-paclitaxel group and one death occurred in the control group.CONCLUSION:
Treatment with LDE-paclitaxel was tolerated by patients with cardiovascular disease and showed the potential to reduce atherosclerotic lesion size.
Texte intégral:
Disponible
Indice:
LILAS (Amériques)
Sujet Principal:
Maladies de l'aorte
/
Cholestérol
/
Paclitaxel
/
Athérosclérose
/
Modulateurs de la polymérisation de la tubuline
/
Nanoparticules
Type d'étude:
Essai clinique contrôlé
/
Facteurs de risque
Limites du sujet:
Adulte très âgé
/
Aged80
/
Femelle
/
Humains
/
Mâle
langue:
Anglais
Texte intégral:
Clinics
Année:
2016
Type:
Article
Institution/Pays d'affiliation:
Universidade de São Paulo/BR
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