Inhibition of formaldehyde-induced arthritis by a purified fraction prepared from Wilbrandia (cf) verticillata which contains novel norcucurbitacin glucosides
Braz. j. med. biol. res
;
22(11): 1397-9, 1989. ilus, tab
Article
Dans Anglais
| LILACS
| ID: lil-83145
ABSTRACT
The anti-inflammatory activity of a purified fraction of the rhizome of Wilbrandia (cf) verticillata, which contains two novel norcucurbitacin glucosides, is reported. The increase of vascular permeability induced by acetic acid in mice (N = 5) was inhibited 69% and 90% by 50 and 100 mg/kg of the purified fraction, po (P<0.01). Acetylsalicylic acid (200 mg/kg), po, inhibited the response by 62% under the same conditions (P<0.05). The purified fraction (100 mg/kg, po) also significantly inhibited paw swelling in the rat formaldehyde-induced arthritis model on 8 of 10 days and reduced the swelling by 63% on day 10. Dexamethasone (1 mg/kg, ip) was more effective than the extract under the same conditions. These data partially characterize the anti-inflammatory activity of the purified fraction from this plant which is used in Brazilian folk medicine for the treatment of arthritis and related disorders
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Indice:
LILAS (Amériques)
Sujet Principal:
Arthrite expérimentale
/
Perméabilité capillaire
/
Extraits de plantes
/
Formaldéhyde
/
Acétates
Limites du sujet:
Animaux
langue:
Anglais
Texte intégral:
Braz. j. med. biol. res
Thème du journal:
Biologie
/
Médicament
Année:
1989
Type:
Article
/
Congrès et conférence
/
descriptif de projet
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