Vitamin E stimulates endotoxin-inhibited monocyte migration and phagocytosis in vivo
Braz. j. med. biol. res
;
22(11): 1401-3, 1989. ilus
Article
Dans Anglais
| LILACS
| ID: lil-83146
ABSTRACT
Intravenous administration of E. coli endotoxin (LPS, 30 microng/kg, iv) inhibited thioglycollatestimulated accumulation of monocytes into the rat peritoneal cavity, measured 48 and 72 h later, by about 40%. Pretreatment of animals with vitamin E (50 mg/kg, im) restored thioglycollate-induced monocyte migration in LPS-challenged rats to control levels. Vitamin E also partially reversed LPS-induced inhibition of monocyte phagocytosis in vivo. The results suggest that vitamin E could be beneficial in restoring leukocyte function in septicemic states
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Indice:
LILAS (Amériques)
Sujet Principal:
Cavité péritonéale
/
Phagocytose
/
Vitamine E
/
Inhibition de la migration cellulaire
/
Monocytes
/
Endotoxines
/
Escherichia coli
Limites du sujet:
Animaux
langue:
Anglais
Texte intégral:
Braz. j. med. biol. res
Thème du journal:
Biologie
/
Médicament
Année:
1989
Type:
Article
/
descriptif de projet
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