Leptospirosis in Barbados: a clinical study
West Indian med. j
;
39(1): 27-34, mar. 1990. tab
Article
Dans Anglais
| LILACS
| ID: lil-87909
ABSTRACT
A 39-month clinical study of leptospirosis was undertaken at the Queen Elizabeth Hospital, Barbados, Eighty-eight patients had a confirmed diagnosis of the disease during the period. The major serogroups identified were autumnalis (including a new serovar bim), icterohaemorrhagiae, ballum and canicola. The majority of patients presented with jaundice (95%,) anorexia and headaches (85%), fever (76%) and conjunctival suffusion (54%). While abnormal creatinine levels were seen in 49% of patients on admission, only 16% were judged to have had renal failure. The urine to plasma urea ratio showed high sensitivity and specificity in the diagnosis of pre-renal azotemia. Cardiac arrhythmias and myocarditis occurred in 18% of patients and pericarditis in 6%. An elevated serum amylase was found in 65% of cases. The bilirubin level took 5.5 weeks to return to normal. Thrombocytopenia was shown not to be due to a disseminated intravascular coagulation, and a randomised trial of high dose penicillin did not reveal any benefit to jaundiced patients. The overall mortality during the study was 5.7%
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Indice:
LILAS (Amériques)
Sujet Principal:
Leptospira interrogans serovar canicola
/
Leptospira interrogans
/
Leptospirose
Type d'étude:
Essai clinique contrôlé
/
Etude diagnostique
/
Étude pronostique
Limites du sujet:
Adolescent
/
Adulte
/
Femelle
/
Humains
/
Mâle
Pays comme sujet:
Barbade
/
Caraïbes anglaises
langue:
Anglais
Texte intégral:
West Indian med. j
Thème du journal:
Médicament
Année:
1990
Type:
Article
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