Bilateral microinjection of ethosuximide into the substantia nigra does not prevent amygdala-kindled seizures

ABSTRACT

Male Wistar rats were sugjected to daily sessions of electrical amygdala kindling until a generalized seixure was observed on five consecutive days. Bilateral microinections (0.5 micronl) of ethosuximide (ETX) (10 pg/micronl) or saline were then administered though guide cannulas into the substantia nigra (pars reticulata). No significant difference was observed between the ETX (N = 8) and saline (N = 8) groups in duration of afterdischarge or in the latency for stage 5 generalized seizures. Our results indicate that ETX applied to the substantia nigra is not effective in suppressing amydala-kindled seizure