The role of opioids in the analgesic response of rats during the estrous cycle
Braz. j. med. biol. res
; 23(11): 1157-9, 1990. tab
Article
de En
| LILACS
| ID: lil-91619
Bibliothèque responsable:
BR26.1
ABSTRACT
The analgesic response was evaluated by the tail immersion test in female rats during each phase of rhe estrous cycle. The reaction time (mean ñ SEM) for tail witdrawal from the hot water bath was faster during proestrus (5.78 ñ 0,28s) and decreased significantly during estrus (5.31 ñ 0.30s) and diestrus 1 (5.40 ñ 0.21s). Blockade of opiate receptors with naloxone (2mg/Kg, ip) invreased the sensitivity to the noxious stimulus only during proestrus (6.46 ñ 0.42 vs 5.02 ñ 0.41 s). These results suggest that the effects of gonadal steroids on nociception may involve an opioid pathway
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Indice:
LILACS
Sujet Principal:
Oestrus
/
Analgésie
/
Naloxone
Limites du sujet:
Animals
langue:
En
Texte intégral:
Braz. j. med. biol. res
Thème du journal:
BIOLOGIA
/
MEDICINA
Année:
1990
Type:
Article
/
Congress and conference