Endogenous hyperinsulinemia and release of growth hormone following a glucose load as well as in reponse to thyrotropin relasisng hormone in acromegaly
Braz. j. med. biol. res
;
23(10): 953-7, 1990. ilus, tab
Article
Dans Anglais
| LILACS
| ID: lil-91631
ABSTRACT
This study was designed to determine the relationship between endogenous hyperinsulinemia or free fatty acid (FFA) levels and the abnormal release of growth hormone (GH) during the oral glucose tolerance test (OGTT) or in response to thyrotropin releasing hormone (TRH) in acromegalic patients. Seventeen patients with acromegaly and nine healthy control subjects were studied. The 12 acromegalic patients who did not show the paradoxical response of increased GH secretion to the OGTT an/or to TRH exhibited higher insulin levels (total area under the curve during the OGTT) than patients who did. However, the FFA levels of the groups of acromegalic patients were similar. These data suggest that the endogenous hyperinsulinemia exhibited by many patients with acromegaly is associated with the absence of the paradoxical increase in GH secretion during the OGTT and/or after TRH
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Indice:
LILAS (Amériques)
Sujet Principal:
Acromégalie
/
Hormone de croissance
/
Hormone de libération de la thyréostimuline
/
Insuline
Type d'étude:
Étude pronostique
Limites du sujet:
Femelle
/
Humains
/
Mâle
langue:
Anglais
Texte intégral:
Braz. j. med. biol. res
Thème du journal:
Biologie
/
Médicament
Année:
1990
Type:
Article
/
Congrès et conférence
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