Praziquantel inhibits Schistosoma mansoni attachment in vitro
Braz. j. med. biol. res
;
23(10): 1005-8, 1990. ilus
Article
Dans Anglais
| LILACS
| ID: lil-91641
ABSTRACT
Male adult Schistosoma mansoni worms were placed in a glass dish containing Tyrode solution and observed for 15 min after addition of praziquantel (0.01 to 1 pmicron M). Praziquantel promoted a concentrationp- and time-dependent inhibition of sucker-mediated attachment of the worm. Attachment inhibition was correlated with shortening of the parasite. We propose that the rapid and total inhibition of worm attachment observed in vitro with 1 micronM praziquantel indicates that therapeutic concentrations of this drug should promote a rapid hepatic shift, in vivo, which may facilitate host tissue reaction
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Indice:
LILAS (Amériques)
Sujet Principal:
Praziquantel
/
Schistosoma mansoni
/
Techniques in vitro
Limites du sujet:
Animaux
langue:
Anglais
Texte intégral:
Braz. j. med. biol. res
Thème du journal:
Biologie
/
Médicament
Année:
1990
Type:
Article
/
Congrès et conférence
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