Correlation between the lack of mononuclear cell cytotoxicity against schistosomula in vitro with schistosomiasis
Braz. j. med. biol. res
;
23(6/7): 577-80, 1990. tab
Article
Dans Anglais
| LILACS
| ID: lil-92206
ABSTRACT
A comparison was made of the reactivity of mononuclear cells from subjects and from S. mansoni-infected patients. The following parameters were evaluated 1) ability of mononuclear cells to kill schistosoma in the presence of complement; 2) [3H]-inositol incorporation into phosphatidylinositol (PI) and the rate of inositolphosphates (IPx) released. Cells from normal subjects, but not from S. mansoni infected patients, were able to kill schistosomula in vitro. A decrease in inositolpolyphosphates (IPx) was observed for phytohemagglutinin (PHA)-stimulated mononuclear cells from infected patients when compared with mononuclear cells from normal subjects after 24 h of incubation. The results suggest that the reactivity of mononuclear cells from infected patients is altered under conditions of nonspecific stimulation with PHA when compared with normal cells
Recherche sur Google
Indice:
LILAS (Amériques)
Sujet Principal:
Phytohémagglutinine
/
Schistosomiase à Schistosoma mansoni
/
Techniques in vitro
/
Agranulocytes
/
Inositol phosphates
Limites du sujet:
Humains
langue:
Anglais
Texte intégral:
Braz. j. med. biol. res
Thème du journal:
Biologie
/
Médicament
Année:
1990
Type:
Article
/
Congrès et conférence
Documents relatifs à ce sujet
MEDLINE
...
LILACS
LIS