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Exogenous ganglioside stimulation of axonal regeneration after new transection and entubulation repair
Braz. j. med. biol. res ; 23(9): 823-6, 1990. ilus
Article Dans Anglais | LILACS | ID: lil-92403
ABSTRACT
Adult male mice received sciatic nerve transection at the midthigh level and both nerve stumps were sutured into a polythylene tube (PT) to bridge a nerve gap of 4 mm. The tubes were implanted either empty, or filled with collagen alone or in combination with gangliosides (GM1, GD1a, GD1b, anhd GT1b). Following a survival time of 6 weeks, the PT with the regenerating nerve cables were processed for plastic embedding, and morphometric measurements were made on myelinated and unmyelinated axons. The data suggest that local application of exogenous gangliosides causes a stimulation of axonal sprouting in vivo with no effefct on the rate of axonal maturation
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Indice: LILAS (Amériques) Sujet Principal: Nerf ischiatique / Gangliosides / Régénération nerveuse Limites du sujet: Animaux langue: Anglais Texte intégral: Braz. j. med. biol. res Thème du journal: Biologie / Médicament Année: 1990 Type: Article / Congrès et conférence

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Indice: LILAS (Amériques) Sujet Principal: Nerf ischiatique / Gangliosides / Régénération nerveuse Limites du sujet: Animaux langue: Anglais Texte intégral: Braz. j. med. biol. res Thème du journal: Biologie / Médicament Année: 1990 Type: Article / Congrès et conférence