Exogenous ganglioside stimulation of axonal regeneration after new transection and entubulation repair
Braz. j. med. biol. res
;
23(9): 823-6, 1990. ilus
Article
Dans Anglais
| LILACS
| ID: lil-92403
ABSTRACT
Adult male mice received sciatic nerve transection at the midthigh level and both nerve stumps were sutured into a polythylene tube (PT) to bridge a nerve gap of 4 mm. The tubes were implanted either empty, or filled with collagen alone or in combination with gangliosides (GM1, GD1a, GD1b, anhd GT1b). Following a survival time of 6 weeks, the PT with the regenerating nerve cables were processed for plastic embedding, and morphometric measurements were made on myelinated and unmyelinated axons. The data suggest that local application of exogenous gangliosides causes a stimulation of axonal sprouting in vivo with no effefct on the rate of axonal maturation
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Indice:
LILAS (Amériques)
Sujet Principal:
Nerf ischiatique
/
Gangliosides
/
Régénération nerveuse
Limites du sujet:
Animaux
langue:
Anglais
Texte intégral:
Braz. j. med. biol. res
Thème du journal:
Biologie
/
Médicament
Année:
1990
Type:
Article
/
Congrès et conférence
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