Inhibition of chlorpromazine-induced catalepsy by the 5-HT-1A ligands pindolol and Buspirone in mice
Braz. j. med. biol. res
;
23(9): 869-71, 1990. ilus
Article
Dans Anglais
| LILACS
| ID: lil-92445
RESUMO
Neuroleptcs such as chlorpromazine and haloperidol are capable of inducing catalepsy in rodents. Non-selective 5-hydroxytryptamine (5-HT) antagonists such as methysergide reduce the cataleptic effect of haloperidol. The present study was designed to evaluate the particpation of 5-HT-1A receptors in chlorpromazine-induced catalepsy in mice. Pundolol and buspirone, two putative 5-HT-1A receptor ligands, were used. Pretreatment with these drugs reduced the cataleptic effect of chlorpromazine. Clomipramine, a 5-HT neuronal uptake blocker, reversed the inhibitory effect of buspirone. Pretreatment with clomipramine alone caused a potentiation of neuroleptic-induced catalepsy. These results suggest that central 5-HT-1A receptors play an important role in neuroleptic-induced catalepsy in mice
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Indice:
LILAS (Amériques)
Sujet Principal:
Pindolol
/
Buspirone
/
Catalepsie
/
Chlorpromazine
/
Clomipramine
/
Halopéridol
Limites du sujet:
Animaux
langue:
Anglais
Texte intégral:
Braz. j. med. biol. res
Thème du journal:
Biologie
/
Médicament
Année:
1990
Type:
Article
/
Congrès et conférence
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