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Use of y-chromosome-specific DNA probes to evaluate an XX male
Braz. j. med. biol. res ; 24(2): 149-56, 1991. tab
Article Dans Anglais | LILACS | ID: lil-99449
ABSTRACT
The function of a Y human chromosomal DNA sequence was evaluated. The Y-5 probe was isolated from a flow-sorted chromosome library and detects Y-specific sequences. The Y-5 probe and other T-specific probes were used to analyze an XX male patient without ambiguous genitalia. DNA sequences from the short arm of the chromosome Y that were detected with pDP1007 and DP105 in the patient's genome explain the testis differentation observed in this case. Failure of the patient's DNA to hybridize to the Y-5 probe shows that the primitive gonads can differentiate into testes even in the absence of this chromosome region. In contrast, a gene controlling spermatogenesis may exist in this region because the patient azoospermic
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Indice: LILAS (Amériques) Sujet Principal: Aberrations des chromosomes sexuels / Détermination du sexe / Chromosome Y / Sondes d'ADN Limites du sujet: Adolescent / Humains / Mâle langue: Anglais Texte intégral: Braz. j. med. biol. res Thème du journal: Biologie / Médicament Année: 1991 Type: Article / Congrès et conférence

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Indice: LILAS (Amériques) Sujet Principal: Aberrations des chromosomes sexuels / Détermination du sexe / Chromosome Y / Sondes d'ADN Limites du sujet: Adolescent / Humains / Mâle langue: Anglais Texte intégral: Braz. j. med. biol. res Thème du journal: Biologie / Médicament Année: 1991 Type: Article / Congrès et conférence