Evaluation of efficacy of methylprednisolone, prednisolone and chlorambucil in idiopathic glomerulonephritis.
J Indian Med Assoc
;
1997 Jun; 95(6): 163-5, 174
Article
Dans Anglais
| IMSEAR
| ID: sea-100592
ABSTRACT
Thirty adults with steroid resistant idiopathic glomerulonephritis were randomly assigned to symptomatic treatment only or to a 6-month course of methylprednisolone and prednisolone alternated with chlorambucil every other month. Patients were followed up for a period of 6 months. At the end of follow-up, 11 out of 15 treated patients were in complete or partial remission as compared with only 3 of 15 control patients. Three of the treated patients were in complete remission, as compared with none of the controls. In the treated group there was a significant improvement of renal functions during follow-up, whereas in the control group renal functions did not show any significant change. None of the patients was dropped from the study because of side-effects. Therefore, it is concluded that pulse steroid and chlorambucil treatment for 6 months favours remission of idiopathic glomerulonephritis in adults and it leads to improvement of renal function.
Texte intégral:
Disponible
Indice:
IMSEAR (Asie du Sud-Est)
Sujet Principal:
Femelle
/
Humains
/
Mâle
/
Méthylprednisolone
/
Prednisolone
/
Chlorambucil
/
Études de suivi
/
Résultat thérapeutique
/
Adulte
/
Association de médicaments
Type d'étude:
Essai clinique contrôlé
/
Étude observationnelle
/
Étude pronostique
langue:
Anglais
Texte intégral:
J Indian Med Assoc
Année:
1997
Type:
Article
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