Effect of chronic treatment with atenolol and prazosin in streptozotocin induced diabetic rats.
Indian J Physiol Pharmacol
;
1996 Jul; 40(3): 220-4
Article
Dans Anglais
| IMSEAR
| ID: sea-106255
ABSTRACT
Diabetes-mellitus was induced in rats by single intravenous injection of (45 mg/kg) streptozotocin (STZ). STZ diabetic rats showed hypertension, decreased cardiac functions, cardiomyopathy and hypercholesterolemia observed at the end of six weeks. Chronic treatment with atenolol (10 mg/kg) for six weeks in the diabetic rats reduced the elevated blood pressure, but failed to prevent STZ induced other complications. Chronic treatment with prazosin (1 mg/kg, po) in the diabetic rats, reduced the elevated blood pressure and also partially prevented hypercholesterolemia, cardiac dysfunctions and in particular the cardiomyopathy. The results suggest that prazosin may be a better option as compared to atenolol in hypertension when it is associated with diabetes mellitus.
Texte intégral:
Disponible
Indice:
IMSEAR (Asie du Sud-Est)
Sujet Principal:
Rats
/
Aténolol
/
Femelle
/
Prazosine
/
Rat Wistar
/
Streptozocine
/
Antagonistes alpha-adrénergiques
/
Antagonistes bêta-adrénergiques
/
Diabète expérimental
/
Hémodynamique
langue:
Anglais
Texte intégral:
Indian J Physiol Pharmacol
Année:
1996
Type:
Article
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