Histobiochemical changes in lung of protein deficient rats following repeated exposures of MIC vapour.
Indian J Physiol Pharmacol
;
1994 Jul; 38(3): 202-6
Article
Dans Anglais
| IMSEAR
| ID: sea-106273
ABSTRACT
Adult male albino rats, maintained on normal or protein deficient diets from weanling, were exposed to repeated doses of MIC vapour (0.32 mg/L for 8 min for 5 consecutive days) under static conditions. Histopathology and the activities of alkaline and acid phosphatases and GSH content of lung were studied upto day 14 after exposure. Mild but repeated exposures of MIC vapour caused severe pulmonary lesions like denudation of bronchiolar epithelial lining tissue, cellular infiltration, edema, emphysema followed by hyperplasia, hypertrophy, fibrosis and intraluminal fibroplasia. The activities of alkaline and acid phosphatases were increased at earlier intervals while GSH content decreased significantly and remained low throughout the experimental duration. Protein deficiency was found to aggravate the toxic potentials of MIC in present condition.
Texte intégral:
Disponible
Indice:
IMSEAR (Asie du Sud-Est)
Sujet Principal:
Carence protéique
/
Rats
/
Acid phosphatase
/
Administration par inhalation
/
Mâle
/
Répartition aléatoire
/
Exposition professionnelle
/
Isocyanates
/
Aérosols
/
Modèles animaux de maladie humaine
langue:
Anglais
Texte intégral:
Indian J Physiol Pharmacol
Année:
1994
Type:
Article
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