Antinociceptive activity of chromophoric chain substituted hemicyaninocolourants.
Indian J Physiol Pharmacol
;
1997 Apr; 41(2): 144-8
Article
Dans Anglais
| IMSEAR
| ID: sea-106399
ABSTRACT
Some of the chromophoric chain substituted hemicyaninocolourants (CCHCs) were synthesized and confirmed on the basis of nitrogen analysis. These were tested for their antinociceptive activity in albino rats against tail flick technique and sodium chloride induced writhing test. Test compounds were given in graded doses (10, 20 and 50 mg/kg, intraperitoneally) and compared with morphine and aspirin as standard controls. Two compounds CCHC-1 and CCHC-2 showed antinociceptive activity in a dose-dependent manner in both the experimental models. The compound CCHC-3 did not exhibit antinociceptive activity to any significant extent.
Texte intégral:
Disponible
Indice:
IMSEAR (Asie du Sud-Est)
Sujet Principal:
Douleur
/
Quinoléines
/
Rats
/
Normes de référence
/
Relation structure-activité
/
Queue
/
Femelle
/
Mâle
/
Chlorure de sodium
/
Anti-inflammatoires non stéroïdiens
langue:
Anglais
Texte intégral:
Indian J Physiol Pharmacol
Année:
1997
Type:
Article
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