Acute neurobehavioural toxicity of phosphamindon and its drug-induced alteration.
Indian J Physiol Pharmacol
;
1990 Apr; 34(2): 101-4
Article
Dans Anglais
| IMSEAR
| ID: sea-106551
ABSTRACT
Phosphamidon, a systemic organophosphate insecticide, (1.4 mg/kg - dose 1/4th of LD50 given ip), produced several autonomic, neurological and behavioral effects in mice with peak effects being at 15 min. Similar dose in rats also abolished conditioned avoidance response. Pre-treatment with atropine, iproniazid, alpha-methyl-p-tyrosine, p-chlorophenylalanine or thiosemicarbazide reduce many of these effects. This suggests that phosphamidon toxicity involves the central cholinergic, adrenergic, serotonergic and GABAergic systems in addition to peripheral cholinergic effects.
Texte intégral:
Disponible
Indice:
IMSEAR (Asie du Sud-Est)
Sujet Principal:
Phosphamidon
/
Rats
/
Lignées consanguines de rats
/
Atropine
/
Semicarbazides
/
Système nerveux autonome
/
Tyrosine 3-monooxygenase
/
Comportement animal
/
Mâle
/
Fenclonine
langue:
Anglais
Texte intégral:
Indian J Physiol Pharmacol
Année:
1990
Type:
Article
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