Nifedipine potentiates gabapentin antinociception in rats.
Indian J Physiol Pharmacol
;
2002 Apr; 46(2): 249-51
Article
Dans Anglais
| IMSEAR
| ID: sea-106644
ABSTRACT
To evaluate the involvement of Ca++ channels in Gabapentin antinociception. In healthy male albino rats formalin (50 microliters, 5%) was injected at the planter surface of the paw. Pain score was calculated. Antinociceptive effect of (10, 30 mg/kg) gabapentin and (3, 10 mg/kg) nifedipine alone and on co-administration of sub analgesic doses was studied 30 minutes after formalin injection and reduction in pain scores was calculated. Gabapentin (30 mg/kg) and nifedipine (10 mg/kg) reduced the pain score in formalin injected rats. Gabapentin (10 mg/kg) and nifedipine (3 mg/kg) given alone did not modify pain score, however, on co-administration they significantly reduced the pain score. Study provides evidence of involvement of Ca++ channels in gabapentin antinociception.
Texte intégral:
Disponible
Indice:
IMSEAR (Asie du Sud-Est)
Sujet Principal:
Rats
/
Mesure de la douleur
/
Mâle
/
Nifédipine
/
Rat Wistar
/
Acides cyclohexanecarboxyliques
/
Synergie des médicaments
/
Acide gamma-amino-butyrique
/
Amines
/
Analgésiques
langue:
Anglais
Texte intégral:
Indian J Physiol Pharmacol
Année:
2002
Type:
Article
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