Autoinhibition and desensitization of serotonergic responses in guinea pig ileum.
Indian J Physiol Pharmacol
;
1988 Jul-Sep; 32(3): 215-20
Article
Dans Anglais
| IMSEAR
| ID: sea-106647
ABSTRACT
The present study was undertaken to investigate the autoinhibition and desensitization of 5-hydroxytryptamine (5-HT) using another agonist MK-212 on guinea pig ileum. 5-HT and MK-212 produced dose dependent contractions of guinea pig ileum. The responses to MK-212 were reduced in the presence of 5-HT and vice versa. Neither 5-HT nor MK-212 produced any change in the responses to histamine, acetylcholine or KCl. Increase in Ca++ in bathing fluid reversed the desensitization produced by MK-212 or 5-HT. Our data suggest that 5-HT and MK-212 produce desensitization which is specific for serotonergic receptors and possibly involves Ca++ ions.
Texte intégral:
Disponible
Indice:
IMSEAR (Asie du Sud-Est)
Sujet Principal:
Pyrazines
/
Relation structure-activité
/
Résistance aux substances
/
Sérotonine
/
Calcium
/
Cochons d'Inde
/
Iléum
/
Animaux
/
Contraction musculaire
langue:
Anglais
Texte intégral:
Indian J Physiol Pharmacol
Année:
1988
Type:
Article
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