Abuse liability of buprenorphine--a study among experienced drug users.
Indian J Physiol Pharmacol
;
1998 Jan; 42(1): 95-100
Article
Dans Anglais
| IMSEAR
| ID: sea-106770
ABSTRACT
Six male post-detoxified opiate dependent subjects were evaluated for abuse liability of buprenorphine (0.6 mg), morphine (16 mg), pentazocine (30 mg) and distilled water (placebo) intramuscular injection in a single blind cross-over random order. Subjective states, drug discrimination, drug linking, sedation and euphoria were assessed at pre-injection, 30 min and 4 hrs post-injection. Buprenorphine caused significant euphoria and was identified as heroin. On all parameters, buprenorphine resembled morphine rather than pentazocine and placebo. The data suggest that abuse liability of buprenorphine is similar to morphine i.e. moderate rather than low.
Texte intégral:
Disponible
Indice:
IMSEAR (Asie du Sud-Est)
Sujet Principal:
Buprénorphine
/
Humains
/
Mâle
/
Enfant
/
Enquêtes et questionnaires
/
Adolescent
/
Adulte
/
Troubles liés à une substance
/
Euphorie
/
Dépendance à l'héroïne
Type d'étude:
Essai clinique contrôlé
/
Recherche qualitative
langue:
Anglais
Texte intégral:
Indian J Physiol Pharmacol
Année:
1998
Type:
Article
Documents relatifs à ce sujet
MEDLINE
...
LILACS
LIS