A study on withdrawal related haemodynamic response in chronic propranolol treated conscious rats.
Indian J Physiol Pharmacol
;
1993 Jul; 37(3): 235-7
Article
Dans Anglais
| IMSEAR
| ID: sea-106800
ABSTRACT
Single dose of propranolol hydrochloride (5 mg/kg, i.p.) caused significant fall in heart rate (HR) but not in systolic blood pressure (SBP) in normotensive conscious rats. Multiple doses of propranolol (5 mg/kg, i.p., twice-a-day for 5 wk) caused significant fall in both HR and SBP at 2 wk and 4 wk in normotensive conscious rats. Sudden withdrawal of propranolol at 5 wk caused a significant blood pressure upswing and tachycardia between 12-24 h followed by normalization of both blood pressure and heart rate. The study documents a possible model of rebound hypertension in normotensive conscious rats.
Texte intégral:
Disponible
Indice:
IMSEAR (Asie du Sud-Est)
Sujet Principal:
Propranolol
/
Rats
/
Syndrome de sevrage
/
Tachycardie
/
Pression sanguine
/
Mâle
/
Rat Wistar
/
Rythme cardiaque
/
Hypertension artérielle
/
Animaux
langue:
Anglais
Texte intégral:
Indian J Physiol Pharmacol
Année:
1993
Type:
Article
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