The cardiac inotropic responses to insulin in the rat heart.
Indian J Physiol Pharmacol
;
1980 Oct-Dec; 24(4): 346-50
Article
Dans Anglais
| IMSEAR
| ID: sea-107030
ABSTRACT
Insulin (5 to 40 I.U.) produced dose-dependent positive inotropic effect in the isolated rat heart. The responses to insulin were markedly inhibited in the presence of propranolol (1 . 1X10(-6) M). Insulin responses were markedly reduced in reserpine pretreated (5 mg/kg, i.p.) rats. Theophylline (4.4 mM), the phosphodiesterase inhibitor, potentiated the responses to insulin, whereas imidazole (20 mM), the phosphodiesterase stimulator inhibited the responses to insulin. The data suggest that the positive inotropic effects of insulin in rat heart is mediated through the release of cardiac catecholamines which stimulates beta-adrenoceptors. The final mediator of cardiac action seems to be cyclic-AMP.
Texte intégral:
Disponible
Indice:
IMSEAR (Asie du Sud-Est)
Sujet Principal:
Propranolol
/
Rats
/
Activation chimique
/
Théophylline
/
Femelle
/
Mâle
/
Interactions médicamenteuses
/
Imidazoles
/
Insuline
/
Animaux
langue:
Anglais
Texte intégral:
Indian J Physiol Pharmacol
Année:
1980
Type:
Article
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