Beta-adrenoreceptor blockade attenuates heat-induced tachycardia,but not the tolerance to the stress.
Indian J Physiol Pharmacol
;
1992 Jul; 36(3): 149-54
Article
Dans Anglais
| IMSEAR
| ID: sea-107050
ABSTRACT
Ten healthy males (age 34 +/- 3 yr 9 SE) underwent 40 min of heat exposure (WD 39.7.C) after 2 hours of ingesting 120 mg of Propranolol (Inderal; ICI), or a placebo, in a random manner, the exposures being about a week apart. That there was no placebo effect was ensured by giving a control run (no medication). In the placebo trials, the end-experiment heart rate had increased by 52%, while after propranolol the increase was only 43%. Regression analysis showed that with the placebo, the HR increased by 22 beats/min/o rise in core (aural) temperature, while with propranolol, the rise (14 beats/min) was significantly lower (P < 0.02). The various heat strain indices viz the Craig's Index, the Body heat storage (Kilocals/m2/hr), and the effective heat storage were also similar for both the treatments. We conclude that beta-adrenoreceptor activity plays a significant role in producing tachycardia of heat exposure in humans, but blocking this activity with propranolol does not affect tolerance to heat stress.
Texte intégral:
Disponible
Indice:
IMSEAR (Asie du Sud-Est)
Sujet Principal:
Propranolol
/
Stress physiologique
/
Tachycardie
/
Pression sanguine
/
Température du corps
/
Humains
/
Mâle
/
Administration par voie orale
/
Récepteurs bêta-adrénergiques
/
Adulte
Type d'étude:
Essai clinique contrôlé
langue:
Anglais
Texte intégral:
Indian J Physiol Pharmacol
Année:
1992
Type:
Article
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