Effect of glucagon on arrhythmias induced by coronary artery occlusion and ouabain in dogs.
Indian J Physiol Pharmacol
;
1980 Oct-Dec; 24(4): 329-34
Article
Dans Anglais
| IMSEAR
| ID: sea-107057
ABSTRACT
The effect of glucagon in arrhythmias induced by coronary artery occlusion and ouabain was studied in dogs. Intravenous administration of glucagon (50 microgram/kg) to 6 dogs with more than 70% ectopic activity after coronary artery occlusion, resulted in significant (P less than 0.01) decrease in ectopics and increase in heart rate. Infusion of glucagon (2.5 microgram/kg/min) for 30 min caused complete elimination of ectopic activity during infusion period. In another series of 7 experiments, glucagon failed to abolish the ouabain-induced ectopic beats. In fact the hormone itself caused a significant (P less tha 0.01) increase in ectopic activity and heart rate. However, in 7 dogs with complete heart block produced after ouabain conversion to normal sinus rhythm was observed after glucagon.
Texte intégral:
Disponible
Indice:
IMSEAR (Asie du Sud-Est)
Sujet Principal:
Ouabaïne
/
Troubles du rythme cardiaque
/
Femelle
/
Mâle
/
Glucagon
/
Vaisseaux coronaires
/
Chiens
/
Électrocardiographie
/
Rythme cardiaque
/
Animaux
langue:
Anglais
Texte intégral:
Indian J Physiol Pharmacol
Année:
1980
Type:
Article
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