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Antiulcer activity and the mechanism of action of magaldrate in gastric ulceration models of rat.
Indian J Physiol Pharmacol ; 2000 Jul; 44(3): 350-4
Article Dans Anglais | IMSEAR | ID: sea-107319
ABSTRACT
The present study was undertaken to investigate the mechanism of cytoprotective effects of magaldrate in aspirin plus pylorus-ligation model and ethanol-induced gastric ulcer model in rats. Magaldrate (60 mg/kg, p.o.) produced a significant reduction in the ulcer index and significant increase in mucus content in ethanol-induced gastric ulceration in rats. In aspirin plus pylorus-ligation model magaldrate produced significant decrease in ulcer index, total acidity and protein content (PR). It did not produce any significant change in volume of gastric secretion. However, it produced significant increase in total carbohydrate (TC) level but not in ratio between TC and proteins. It also produced a significant decrease in lipid peroxidation (as expressed by thiobarbituric acid reactive substance). Our data suggests the cytoprotective action of magaldrate on gastric mucosal cells which may be due to protection of gastric mucosa from lipid peroxidation.
Sujets)
Texte intégral: Disponible Indice: IMSEAR (Asie du Sud-Est) Sujet Principal: Rats / Ulcère gastrique / Femelle / Mâle / Peroxydation lipidique / Éthanol / Hydroxyde d'aluminium / Muqueuse gastrique / Animaux / Hydroxyde de magnésium langue: Anglais Texte intégral: Indian J Physiol Pharmacol Année: 2000 Type: Article

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Texte intégral: Disponible Indice: IMSEAR (Asie du Sud-Est) Sujet Principal: Rats / Ulcère gastrique / Femelle / Mâle / Peroxydation lipidique / Éthanol / Hydroxyde d'aluminium / Muqueuse gastrique / Animaux / Hydroxyde de magnésium langue: Anglais Texte intégral: Indian J Physiol Pharmacol Année: 2000 Type: Article