Effect of macrocomponents of food on the pharmacokinetics of a long acting preparation of anhydrous theophylline.
Indian J Physiol Pharmacol
;
1993 Oct; 37(4): 303-7
Article
Dans Anglais
| IMSEAR
| ID: sea-107343
ABSTRACT
In a single dose crossover study, the effect of macrocomponents of food on the pharmacokinetics of a long acting preparation of anhydrous theophylline was investigated. Compared to fasting subjects, carbohydrate and fat rich diet caused an enhancement of absorption half life and a lower Cmax with a delayed tmax and elimination of the bronchodilator. Protein coadministration decreased AUCO-OC of the drug without significantly altering its absorption or elimination kinetics.
Texte intégral:
Disponible
Indice:
IMSEAR (Asie du Sud-Est)
Sujet Principal:
Théophylline
/
Femelle
/
Humains
/
Mâle
/
Hydrates de carbone alimentaires
/
Matières grasses alimentaires
/
Protéines alimentaires
/
Jeûne
/
Adulte
/
Préparations à action retardée
Type d'étude:
Essai clinique contrôlé
langue:
Anglais
Texte intégral:
Indian J Physiol Pharmacol
Année:
1993
Type:
Article
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