Central serotonergic and histaminergic modulation of peripheral inflammation and nociception in rats.
Indian J Physiol Pharmacol
;
1996 Apr; 40(2): 163-6
Article
Dans Anglais
| IMSEAR
| ID: sea-107694
ABSTRACT
Possible central serotonergic and histaminergic modulation of acute peripheral inflammation was investigated in rats, adopting the formaldehyde-induced acute pedal inflammation as an experimental model. Intracerebroventricular (icv) administration of central inhibitory neurotransmitter, serotonin and its precursor, 5-hydroxytryptophan (5-HTP) attenuated the oedema volume and exudate protein content alongwith augmentation in pain threshold. On the contrary, cyproheptadine, a 5-HT-receptor antagonist and selective serotonin synthesis inhibitor, parachlorophenylalanine (PCPA) produced oedema augmenting and pro-nociceptive effects besides elevating the protein content of the exudate. Centrally administered histamine attenuated pedal oedema, nociception as well as protein concentration in oedema fluid. Cimetidine, an H2 histaminergic receptor blocker did not produce any significant effect on inflammation.
Texte intégral:
Disponible
Indice:
IMSEAR (Asie du Sud-Est)
Sujet Principal:
Douleur
/
Rats
/
Antisérotonines
/
Facteurs temps
/
Nocicepteurs
/
Mâle
/
Histamine
/
Sérotonine
/
Agonistes des récepteurs de la sérotonine
/
Rat Sprague-Dawley
Type d'étude:
Étude pronostique
langue:
Anglais
Texte intégral:
Indian J Physiol Pharmacol
Année:
1996
Type:
Article
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